2416418-11-4
Chemical Structure
MYF-03-69
Synonym(s): TEAD-IN-3
- CAS No.: 2416418-11-4
- Formula:C22H20F3N5O2
- Molecular Weight:443.42
IUPAC Name: 1-((3R,4R)-3-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)-4-((4-(trifluoromethyl)benzyl)oxy)pyrrolidin-1-yl)prop-2-en-1-one
InChIKey: AZGCPBIUNCLWPF-WOJBJXKFSA-N
SMILES: FC(F)(F)C(C=C1)=CC=C1CO[C@H]2[C@@](N3C=C(C4=CN=CC=C4)N=N3)([H])CN(C2)C(C=C)=O
Biological Activity: MYF-03-69 (TEAD-IN-3) is a covalent and irreversible TEAD inhibitor with IC50s of 385, 143, 558 and 173 nM for TEAD1, TEAD2, TEAD3 and TEAD4. MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50 = 56 nM) and up-regulates apoptosis gene BMF. MYF-03-69 selectively inhibits mesothelioma cancer cells with defective Hippo signaling. MYF-03-69 can be used for the study of malignant pleural mesothelioma (MPM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MYF-03-69 | 98.11% | MYF-03-69 (TEAD-IN-3) is a covalent and irreversible TEAD inhibitor with IC50s of 385, 143, 558 and 173 nM for TEAD1, TEAD2, TEAD3 and TEAD4. MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50 = 56 nM) and up-regulates apoptosis gene BMF. MYF-03-69 selectively inhibits mesothelioma cancer cells with defective Hippo signaling. MYF-03-69 can be used for the study of malignant pleural mesothelioma (MPM). | ||||||||||||||||||||
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