244291-63-2
244291-63-2
Chemical Structure
AC-42
- CAS No.: 244291-63-2
- Formula:C20H31NO
- Molecular Weight:301.47
IUPAC Name: 4-(4-butylpiperidin-1-yl)-1-(o-tolyl)butan-1-one
InChIKey: ANTKBACNWQHQJE-UHFFFAOYSA-N
SMILES: O=C(CCCN1CCC(CC1)CCCC)C2=CC=CC=C2C
Biological Activity: AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells[1][2].
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AC-42 | AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells. | |||||||||||||||||||||
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References
- [1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. [Content Brief]
- [2]. Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. [Content Brief]
