2445448-66-6
2445448-66-6
Chemical Structure
MYX1715
Synonym(s): IMP1320
- CAS No.: 2445448-66-6
- Formula:C25H29ClN6O2
- Molecular Weight:480.99
InChIKey: AMLXJNZNGSKREP-UHFFFAOYSA-N
SMILES: O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2
Biological Activity: MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MYX1715 | 99.55% | MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin. | ||||||||||||||||||||
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References
- [1]. Zhang J, et al. Dysregulation of MYC-Family Proteins Sensitises Cancers to NMT Inhibition: Identification of NMTi Sensitivity and Mechanism[J]. Cancer Research, 2023, 83(7_Supplement): 4871-4871.
- [2]. Carr R, et al. N-Myristoyltransferase (NMT) inhibitors are completely novel payloads for Antibody Drug Conjugates that deliver extensive tumor regression at well tolerated doses[J].
Keywords
