MYX1715
Based on 1 Customer Validation
MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin.
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- Pureté : 99.55%
- CAS No.: 2445448-66-6
- Formule: C25H29ClN6O2
- Masse moléculaire:480.99
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Th-MYCN GEMM mice model, DLBCL xenograft mice model and gastric cancer xenograft mice model[1]
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Dosage:12.5 and 25 mg/kg
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Administration:a single dose for 20 days
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Result:Inhibited tumour growth in mice bearing tumors.
Chemical Information
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CAS No. 2445448-66-6
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Appearance Solid
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Masse moléculaire 480.99
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Formule C25H29ClN6O2
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Color Yellow to brown
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SMILES
O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2
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Synonyms
IMP1320
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (259.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0790 mL | 10.3952 mL | 20.7905 mL | 51.9761 mL |
| 5 mM | 0.4158 mL | 2.0790 mL | 4.1581 mL | 10.3952 mL | |
| 10 mM | 0.2079 mL | 1.0395 mL | 2.0790 mL | 5.1976 mL | |
| 15 mM | 0.1386 mL | 0.6930 mL | 1.3860 mL | 3.4651 mL | |
| 20 mM | 0.1040 mL | 0.5198 mL | 1.0395 mL | 2.5988 mL | |
| 25 mM | 0.0832 mL | 0.4158 mL | 0.8316 mL | 2.0790 mL | |
| 30 mM | 0.0693 mL | 0.3465 mL | 0.6930 mL | 1.7325 mL | |
| 40 mM | 0.0520 mL | 0.2599 mL | 0.5198 mL | 1.2994 mL | |
| 50 mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 1.0395 mL | |
| 60 mM | 0.0347 mL | 0.1733 mL | 0.3465 mL | 0.8663 mL | |
| 80 mM | 0.0260 mL | 0.1299 mL | 0.2599 mL | 0.6497 mL | |
| 100 mM | 0.0208 mL | 0.1040 mL | 0.2079 mL | 0.5198 mL |
MYX1715 Related Classifications
HY-164285 Related Classifications
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