2447061-40-5
Chemical Structure
S1427
- CAS No.: 2447061-40-5
- Formula:C25H29F3N4O2
- Molecular Weight:474.52
IUPAC Name: 2-(((1S,2R)-2-(3,5-difluoro-2-((2-fluoropyridin-3-yl)methoxy)phenyl)cyclopropyl)amino)-1-(2,8-diazaspiro[4.5]decan-8-yl)ethan-1-one
InChIKey: AOUYVKAMPAJOPE-NQIIRXRSSA-N
SMILES: O=C(N1CCC2(CC1)CCNC2)CN[C@H]3C[C@@H]3C4=C(C(F)=CC(F)=C4)OCC5=CC=CN=C5F
Biological Activity: S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells[1].
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S1427 | S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells. | |||||||||||||||||||||
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Keywords
