245515-64-4
Chemical Structure
CRX-526
- CAS No.: 245515-64-4
- Formula:C69H127N2O19P
- Molecular Weight:1319.72
IUPAC Name: O-((2R,3R,4R,5S,6R)-3-((R)-3-(hexanoyloxy)tetradecanamido)-4-(((R)-3-(hexanoyloxy)tetradecanoyl)oxy)-6-(hydroxymethyl)-5-(phosphonooxy)tetrahydro-2H-pyran-2-yl)-N-((R)-3-(hexanoyloxy)tetradecanoyl)-L-serine
InChIKey: PRIXXGNJDNLMBH-DPGPRPECSA-N
SMILES: O=C([C@H](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OP(O)(O)=O)CO)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)O
Biological Activity: CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model)[1].
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CRX-526 | CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model). | |||||||||||||||||||||
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