2459932-81-9
2459932-81-9
Chemical Structure
EGFR-IN-49
- CAS No.: 2459932-81-9
- Formula:C22H15N5O2S
- Molecular Weight:413.45
IUPAC Name: N-(3-((2-((3-cyanophenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
InChIKey: DUPFAGNYEYZTGC-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(OC2=NC(NC3=CC=CC(C#N)=C3)=NC4=C2SC=C4)=CC=C1)=O
Biological Activity: EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner[1].
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EGFR-IN-49 | EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner. | |||||||||||||||||||||
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