EGFR-IN-49 

EGFR-IN-49 is a potent and selective EGFR inhibitor with IC₅₀s of 65.0 nM and 13.6 nM for EGFR^T790M and EGFR^T790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner^[1].

EGFR-IN-49 (compound 13a) (1, 10 µM) shows inhibition activity for H1975 cells with an IC₅₀ of 699.2 nM^[1].
EGFR-IN-49 (1 µM) shows an strong inhibitory activity to EGFR^T790M, EGFR^T790M/L858R, EGFR^WT with IC₅₀s of 65.0, 13.6, >1000 nM, respectively^[1].
EGFR-IN-49 (0.2, 4, 8 µM; 48 h) induces cell apoptosis in a dose-dependent manner in A431 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

413.45

C₂₂H₁₅N₅O₂S

2459932-81-9

C=CC(NC1=CC(OC2=NC(NC3=CC=CC(C#N)=C3)=NC4=C2SC=C4)=CC=C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xiao Z, et al. Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations. Eur J Med Chem. 2020 Oct 1;203:112511.  [Content Brief]