2459963-17-6
Chemical Structure
TP0427736 hydrochloride
- CAS No.: 2459963-17-6
- Formula:C14H11ClN4S2
- Molecular Weight:334.85
IUPAC Name: 6-(5-(4-methylthiazol-2-yl)-1H-imidazol-4-yl)benzo[d]thiazole hydrochloride
InChIKey: DBKPLYNIVZJPCU-UHFFFAOYSA-N
SMILES: CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)N=CN2)=N1.[H]Cl
Biological Activity: TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].
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TP0427736 hydrochloride | 99.91% | TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA). | ||||||||||||||||||||
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