2477725-07-6
2477725-07-6
Chemical Structure
B-Raf IN 7
- CAS No.: 2477725-07-6
- Formula:C15H16N6O3
- Molecular Weight:328.33
IUPAC Name: ethyl 5-amino-1-(4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-1H-1,2,3-triazole-4-carboxylate
InChIKey: RLEPXWMHUBHGBD-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)N(C2=CC=C(C(CC3)=NNC3=O)C=C2)N=N1)OCC
Biological Activity: B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].
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B-Raf IN 7 | B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM. | |||||||||||||||||||||
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