2484757-41-5
Chemical Structure
Ketodarolutamide-d3
Synonym(s): BAY 1896953-d3; ORM-15341-d3
- CAS No.: 2484757-41-5
- Formula:C19H14D3ClN6O2
- Molecular Weight:399.85
InChIKey: GMBPVBVTPBWIKC-XTRIYBSESA-N
SMILES: ClC1=C(C=CC(C2=NN(C[C@H](C)NC(C3=NNC(C(C([2H])([2H])[2H])=O)=C3)=O)C=C2)=C1)C#N
Biological Activity: Ketodarolutamide-d3 (BAY 1896953-d3) is the deuterium labeled Ketodarolutamide (HY-19337). Ketodarolutamide (ORM-15341) is a potent, high-affinity nonsteroidal competitive full antagonist of androgen receptor (AR). Ketodarolutamide displays a Ki value of 8 nM for rat wild-type AR and an IC50 value of 38 nM in AR-HEK293 cells[1]. Ketodarolutamide inhibits testosterone-induced nuclear translocation of the AR and antagonizes both overexpressed and mutant ARs[1]. Ketodarolutamide specifically suppresses the proliferation of AR-dependent prostate cancer cells and exhibits antitumor activity in models of castration-resistant prostate cancer (CRPC) [1][2]. Ketodarolutamide is suitable for the mechanistic and therapeutic research of prostate cancer[1][2].
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Ketodarolutamide-d3 | Ketodarolutamide-d3 (BAY 1896953-d3) is the deuterium labeled Ketodarolutamide (HY-19337). Ketodarolutamide (ORM-15341) is a potent, high-affinity nonsteroidal competitive full antagonist of androgen receptor (AR). Ketodarolutamide displays a Ki value of 8 nM for rat wild-type AR and an IC50 value of 38 nM in AR-HEK293 cells. Ketodarolutamide inhibits testosterone-induced nuclear translocation of the AR and antagonizes both overexpressed and mutant ARs. Ketodarolutamide specifically suppresses the proliferation of AR-dependent prostate cancer cells and exhibits antitumor activity in models of castration-resistant prostate cancer (CRPC) . Ketodarolutamide is suitable for the mechanistic and therapeutic research of prostate cancer. | |||||||||||||||||||||
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Keywords
