2484811-52-9
Chemical Structure
ATX inhibitor 15
- CAS. Nr.: 2484811-52-9
- Formula:C27H32ClN5O4S
- Molecular Weight:558.09
IUPAC Name: 1-(5-(4-((bis(2-hydroxyethyl)amino)methyl)thiazol-2-yl)-1-ethyl-1H-indol-3-yl)-3-(3-chloro-4-methoxybenzyl)urea
InChIKey: VVRQIPXYZCQXAH-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(C(Cl)=C1)OC)NC2=CN(CC)C3=C2C=C(C4=NC(CN(CCO)CCO)=CS4)C=C3
Biological Activity: ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].
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ATX inhibitor 15 | ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model. | |||||||||||||||||||||
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