249762-74-1
249762-74-1
Chemical Structure
D-65476
- CAS No.: 249762-74-1
- Formula:C21H18N2O3
- Molecular Weight:346.38
IUPAC Name: 2-(1H-indole-2-carbonyl)-1H-indol-5-yl butyrate
InChIKey: CZDUJGOCEPWCNA-UHFFFAOYSA-N
SMILES: O=C(CCC)OC1=CC2=C(NC(C(C3=CC4=C(N3)C=CC=C4)=O)=C2)C=C1
Biological Activity: D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1].
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D-65476 | D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia. | |||||||||||||||||||||
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Keywords
