2499499-62-4
2499499-62-4
Chemical Structure
BRAF V600E/CRAF-IN-2
- CAS No.: 2499499-62-4
- Formula:C30H30F3N5O2
- Molecular Weight:549.59
IUPAC Name: 3-(4-ethylpiperazin-1-yl)-N-(3-((5-methoxyquinolin-2-yl)amino)phenyl)-5-(trifluoromethyl)benzamide
InChIKey: OTASYYGEHSXRJI-UHFFFAOYSA-N
SMILES: CCN1CCN(CC1)C2=CC(C(F)(F)F)=CC(C(NC3=CC=CC(NC4=NC5=CC=CC(OC)=C5C=C4)=C3)=O)=C2
Biological Activity: BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].
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BRAF V600E/CRAF-IN-2 | BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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