2499966-67-3
2499966-67-3
Chemical Structure
FLT3-IN-12
- CAS No.: 2499966-67-3
- Formula:C21H23F3N6O
- Molecular Weight:432.44
IUPAC Name: 6-((4-(((1s,4s)-4-aminocyclohexyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-methylisoquinolin-1(2H)-one
InChIKey: LSEAQLOYCHTEOK-OKILXGFUSA-N
SMILES: O=C1C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@@H]4CC[C@@H](CC4)N)=N3)C=C2C=CN1C
Biological Activity: FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC50 of 0.75 nM)[1].
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FLT3-IN-12 | FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC50 of 0.75 nM). | |||||||||||||||||||||
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