250159-76-3
Chemical Structure
ETM-305
- CAS No.: 250159-76-3
- Formula:C15H15NO6
- Molecular Weight:305.29
IUPAC Name: (E)-7-acetyl-6-(2-formamidovinyl)-4-methylbenzo[d][1,3]dioxol-5-yl acetate
InChIKey: JQRCKPWOPOQUNP-SNAWJCMRSA-N
SMILES: C(C)(=O)C1=C2C(=C(C)C(OC(C)=O)=C1/C=C/NC=O)OCO2
Biological Activity: ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer[1][2][3][4].
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ETM-305 | ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer. | |||||||||||||||||||||
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References
- [1]. Brandon EF, et al. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006;24(1):3-14. [Content Brief]
- [2]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15. [Content Brief]
- [3]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Aug 14;221(2):128-36. [Content Brief]
- [4]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44. [Content Brief]
