2505339-87-5
Chemical Structure
BR103354
- CAS No.: 2505339-87-5
- Formula:C19H15F2N5O2S
- Molecular Weight:415.42
InChIKey: PRKFSEKNKYVALC-AWEZNQCLSA-N
SMILES: O=C(C1=CSC(CC2=CC=C(C=C2)C#N)=N1)NCC(N3[C@@H](CC(F)(C3)F)C#N)=O
Biological Activity: BR103354 is an orally active, selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 14 nM against hFAP. BR103354 restores the levels of phosphorylated ERK and Glut1 that are reduced by co-treatment with hFGF21 and FAP, decreases non-fasting blood glucose concentrations, improves glucose tolerance, and reduces hepatic triglyceride content. BR103354 ameliorates hepatic steatosis and hepatic fibrosis. BR103354 can be used in the research of type 2 diabetes and non-alcoholic steatohepatitis[1].
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BR103354 | BR103354 is an orally active, selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 14 nM against hFAP. BR103354 restores the levels of phosphorylated ERK and Glut1 that are reduced by co-treatment with hFGF21 and FAP, decreases non-fasting blood glucose concentrations, improves glucose tolerance, and reduces hepatic triglyceride content. BR103354 ameliorates hepatic steatosis and hepatic fibrosis. BR103354 can be used in the research of type 2 diabetes and non-alcoholic steatohepatitis. | |||||||||||||||||||||
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Keywords
