25087-26-7
Chemical Structure
Poly(methacrylic acid)
Synonym(s): PMAA
- CAS No.: 25087-26-7
- Formula:(C4H6O2)n
- Molecular Weight:N/A
SMILES: CCC(C)(C(O)=O)C.[n]
Biological Activity: Poly(methacrylic acid) (PMAA) is a pH/ionic strength-responsive swelling agent and polycation complexing agent. Poly(methacrylic acid) undergoes reversible swelling and size changes through carboxylic acid ionization and sodium ion charge shielding. As a weak polyacid, Poly(methacrylic acid) forms cross-linked hydrogels and hollow capsules for the entrapment and storage of macromolecules. Poly(methacrylic acid) forms electrostatic complexes with polycations to reduce capsule permeability, and high-salt conditions disrupt such complexes to enable macromolecule release[1][2][3].
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Poly(methacrylic acid) | Poly(methacrylic acid) (PMAA) is a pH/ionic strength-responsive swelling agent and polycation complexing agent. Poly(methacrylic acid) undergoes reversible swelling and size changes through carboxylic acid ionization and sodium ion charge shielding. As a weak polyacid, Poly(methacrylic acid) forms cross-linked hydrogels and hollow capsules for the entrapment and storage of macromolecules. Poly(methacrylic acid) forms electrostatic complexes with polycations to reduce capsule permeability, and high-salt conditions disrupt such complexes to enable macromolecule release. | |||||||||||||||||||||
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References
- [1]. Kozlovskaya V, Kharlampieva E, Mansfield M L, et al. Poly (methacrylic acid) hydrogel films and capsules: response to pH and ionic strength, and encapsulation of macromolecules[J]. Chemistry of materials, 2006, 18(2): 328-336.
- [2]. Gunther EC, et al. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists. Cell Rep. 2019 Jan 2;26(1):145-158.e8. [Content Brief]
- [3]. Garcıa D M, et al. Synthesis and characterization of poly (methacrylic acid) hydrogels for metoclopramide delivery[J]. European Polymer Journal, 2004, 40(8): 1637-1643.
