Poly(methacrylic acid)
Poly(methacrylic acid) (PMAA) is a pH/ionic strength-responsive swelling agent and polycation complexing agent. Poly(methacrylic acid) undergoes reversible swelling and size changes through carboxylic acid ionization and sodium ion charge shielding. As a weak polyacid, Poly(methacrylic acid) forms cross-linked hydrogels and hollow capsules for the entrapment and storage of macromolecules. Poly(methacrylic acid) forms electrostatic complexes with polycations to reduce capsule permeability, and high-salt conditions disrupt such complexes to enable macromolecule release.
For research use only. We do not sell to patients.
- CAS No.: 25087-26-7
- Formula: (C4H6O2)n
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Poly(methacrylic acid) can serve as a biocompatible hydrogel matrix to achieve non-Fickian, pH-dependent in vitro controlled release of Metoclopramide hydrochloride (HY-17382)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 25087-26-7
-
Formula (C4H6O2)n
-
SMILES
CCC(C)(C(O)=O)C.[n]
-
Synonyms
PMAA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly(methacrylic acid) Related Classifications
HY-184755 Related Classifications
Powered by Bioz
Keywords