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Cat. No.: HY-184820

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Poly(methacrylic acid) sodium

(Synonyms: PMAA sodium)

Poly(methacrylic acid) sodium is a pH/ionic strength-responsive swelling agent and polycation complexing agent. Poly(methacrylic acid) sodium undergoes reversible swelling and size changes through carboxylic acid ionization and sodium ion charge shielding. As a weak polyacid, Poly(methacrylic acid) sodium forms cross-linked hydrogels and hollow capsules for the entrapment and storage of macromolecules. Poly(methacrylic acid) sodium forms electrostatic complexes with polycations to reduce capsule permeability, and high-salt conditions disrupt such complexes to enable macromolecule release.

For research use only. We do not sell to patients.

CAS No.: 54193-36-1
Formula: (C₄H₆O₂)x·xNa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Poly(methacrylic acid) sodium Chemical Structure

CAS No.: 54193-36-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Sodium poly(methacrylic acid) can serve as a biocompatible hydrogel matrix to achieve non-Fickian, pH-dependent in vitro controlled release of Metoclopramide hydrochloride (HY-17382)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 54193-36-1
Formula (C₄H₆O₂)x·xNa
SMILES

O=C(O[Na])C(CC)(C)C.[x]
Synonyms

PMAA sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kozlovskaya V, Kharlampieva E, Mansfield M L, et al. Poly (methacrylic acid) hydrogel films and capsules: response to pH and ionic strength, and encapsulation of macromolecules[J]. Chemistry of materials, 2006, 18(2): 328-336.

[2]. Gunther EC, et al. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists. Cell Rep. 2019 Jan 2;26(1):145-158.e8. [Content Brief]

[3]. Garcıa D M, et al. Synthesis and characterization of poly (methacrylic acid) hydrogels for metoclopramide delivery[J]. European Polymer Journal, 2004, 40(8): 1637-1643.

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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