251908-92-6
Chemical Structure
AM1172
- CAS No.: 251908-92-6
- Formula:C27H39NO2
- Molecular Weight:409.60
IUPAC Name: 4-hydroxy-N-((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl)benzamide
InChIKey: XCWBOAHOJHPWLA-DOFZRALJSA-N
SMILES: O=C(NCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C1=CC=C(O)C=C1
Biological Activity: AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation[1][2][3].
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AM1172 | AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation. | |||||||||||||||||||||
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- [1]. Fegley D, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8756-61. [Content Brief]
- [2]. Kaczocha M, et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J Biol Chem. 2006 Apr 7;281(14):9066-75. [Content Brief]
Keywords
