2522599-69-3
Chemical Structure
Neuroprotective agent 12
- CAS No.: 2522599-69-3
- Formula:C23H28N2O3
- Molecular Weight:380.48
InChIKey: YJYBLWAGHIXNNY-OQLLNIDSSA-N
SMILES: COC1=C(OC2CCCC2)C=CC(/C=C/C(NC3=CC=C(N(C)C)C=C3)=O)=C1
Biological Activity: Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases[1].
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Neuroprotective agent 12 | Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases. | |||||||||||||||||||||
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