252870-53-4
252870-53-4
Chemical Structure
Ispronicline
Synonym(s): TC-1734; ACD3480
- CAS. Nr.: 252870-53-4
- Formula:C14H22N2O
- Molecular Weight:234.34
IUPAC Name: (S,E)-5-(5-isopropoxypyridin-3-yl)-N-methylpent-4-en-2-amine
InChIKey: RPCVIAXDAUMJJP-PZBABLGHSA-N
SMILES: C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1
Biological Activity: Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].
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Ispronicline | 98.24% | Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR. | ||||||||||||||||||||
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