2563855-03-6
2563855-03-6
Chemical Structure
K-975
- CAS No.: 2563855-03-6
- Formula:C16H14ClNO2
- Molecular Weight:287.74
IUPAC Name: N-(3-(4-chlorophenoxy)-4-methylphenyl)acrylamide
InChIKey: KPXAHQSIROUBPH-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O
Biological Activity: K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K-975 | 99.89% | K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma. | ||||||||||||||||||||
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References
Keywords
