2567913-75-9
Chemical Structure
MG-1102
- CAS No.: 2567913-75-9
- Formula:C22H18N4OS
- Molecular Weight:386.47
InChIKey: JLWKAIUMWRZNJT-UHFFFAOYSA-N
SMILES: COC1=CC(C=CC(C2=NNC=C2CN3C=CC=C3C4=NC=CS4)=C5)=C5C=C1
Biological Activity: MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC50s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a Kd of 3.21 mM by surface plasmon resonance (SPR). MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD)[1].
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MG-1102 | MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC50s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a Kd of 3.21 mM by surface plasmon resonance (SPR). MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD). | |||||||||||||||||||||
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Keywords
