2568277-42-7

PROTAC SMARCA2 degrader-12 Chemical Structure
2568277-42-7

Chemical Structure

PROTAC SMARCA2 degrader-12

  • CAS No.: 2568277-42-7
  • Formula:C49H57N11O5S
  • Molecular Weight:912.11

InChIKey: COTZOCMIARZGQO-USQIPHKZSA-N

SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=CC[C@@H](C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)CC6)C=N5)C(CC4)C3

Biological Activity: SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

Cat. No. Product Name Purity Description Pricing
HY-163874 		PROTAC SMARCA2 degrader-12 SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.
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