2570904-69-5
Chemical Structure
Adenosine receptor antagonist 7
- CAS No.: 2570904-69-5
- Formula:C21H22N6O2
- Molecular Weight:390.44
InChIKey: PMYVFCVHHSNNIQ-MRXNPFEDSA-N
SMILES: NC1=NC(N2C=CN=C2)=C(C(C3=CC(N4CC[C@H](C4)OC)=CC(OC)=C3)=C1)C#N
Biological Activity: Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with Ki values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC50 = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer[1].
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Adenosine receptor antagonist 7 | Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with Ki values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC50 = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer. | |||||||||||||||||||||
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