257641-01-3
Chemical Structure
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
- CAS No.: 257641-01-3
- Formula:C10H18N2O2S2
- Molecular Weight:262.39
IUPAC Name: N,N'-((1R,2R)-cyclohexane-1,2-diyl)bis(2-mercaptoacetamide)
InChIKey: XMKXCDBWFOFXJS-HTQZYQBOSA-N
SMILES: SCC(N[C@H]1[C@@H](CCCC1)NC(CS)=O)=O
Biological Activity: (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research[1].
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(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane | (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research. | |||||||||||||||||||||
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