2587588-33-6
Chemical Structure
BODIPY-DOH
- CAS No.: 2587588-33-6
- Formula:C32H22BF2N3O4
- Molecular Weight:561.34
InChIKey: NYZPSXREANQTIG-UHFFFAOYSA-N
SMILES: [F-][B+3]1([N]2=C(C3=CC(O)=C(O)C=C3)C=C(C4=CC=CC=C4)C2=NC5=C(C6=CC=CC=C6)C=C([N-]51)C7=CC=C(C(O)=C7)O)[F-]
Biological Activity: BODIPY-DOH is a reversible near-infrared photoacoustic/fluorescence dual-modal redox probe. BODIPY-DOH undergoes conversion of its catechol group to o-quinone upon oxidation by O2•-, causing a red shift of the absorption peak from 680 nm to 750 nm, and can be reduced and restored by L-Glutathione reduced (GSH) (HY-D0187), thereby achieving a reversible response of the PA750/PA680 ratiometric signal (fluorescence Ex = 633 nm; photoacoustic dual-channel at 680/750 nm). BODIPY-DOH is applicable for research in tumor oxidative microenvironment imaging, spinal cord injury, and other oxidative stress-related disease fields[1][2].
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BODIPY-DOH | BODIPY-DOH is a reversible near-infrared photoacoustic/fluorescence dual-modal redox probe. BODIPY-DOH undergoes conversion of its catechol group to o-quinone upon oxidation by O2•-, causing a red shift of the absorption peak from 680 nm to 750 nm, and can be reduced and restored by L-Glutathione reduced (GSH) (HY-D0187), thereby achieving a reversible response of the PA750/PA680 ratiometric signal (fluorescence Ex = 633 nm; photoacoustic dual-channel at 680/750 nm). BODIPY-DOH is applicable for research in tumor oxidative microenvironment imaging, spinal cord injury, and other oxidative stress-related disease fields. | |||||||||||||||||||||
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References
- [1]. Zheng J, et al. Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo. Journal of the American Chemical Society. 2019 Dec 11;141(49):19226-19230.
- [2]. Ji Z, et al. Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual-Signal Transform-Based Selenium Antioxidant. Small (Weinheim an der Bergstrasse, Germany). 2023 Aug;19(35):e2207888.
