2607871-93-0
Chemical Structure
Remdesivir de(ethylbutyl 2-aminopropanoate)
- No. CAS: 2607871-93-0
- Formula:C18H18N5O7P
- Molecular Weight:447.34
IUPAC Name: ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl phenyl hydrogen phosphate
InChIKey: MRXDDYZPVOXRJV-IIVZCXTMSA-N
SMILES: N#C[C@@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)O[C@@H]1CO[P](OC4=CC=CC=C4)(O)=O
Biological Activity: Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].
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Remdesivir de(ethylbutyl 2-aminopropanoate) | Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro. | |||||||||||||||||||||
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References
- [1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2):e00221-18. [Content Brief]
- [2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]
