261155-87-7
Chemical Structure
C2 Adamantanyl globotriaosylceramide (d18:1/2:0)
Synonym(s): AdaGb3; Adamantyl Gb3; C2 Adamantanyl Ceramide Trihexoside (d18:1/2:0)
- CAS No.: 261155-87-7
- Formula:C48H83NO18
- Molecular Weight:962.17
InChIKey: ATWPTPSAHLZMMT-ZFPSYUDWSA-N
SMILES: OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O[C@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO)CO)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CC45CC6CC(CC(C6)C5)C4)=O
Biological Activity: C2 Adamantanyl globotriaosylceramide (d18:1/2:0) (AdaGb3), a water-soluble globotriaosylceramide analog, is a bioactive sphingolipid. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) reverses MDR1-MDCK cell drug resistance. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) has high affinity for verotoxin (VT)[1][2].
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C2 Adamantanyl globotriaosylceramide (d18:1/2:0) | C2 Adamantanyl globotriaosylceramide (d18:1/2:0) (AdaGb3), a water-soluble globotriaosylceramide analog, is a bioactive sphingolipid. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) reverses MDR1-MDCK cell drug resistance. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) has high affinity for verotoxin (VT). | |||||||||||||||||||||
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References
- [1]. De Rosa MF, et al. Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog. J Biol Chem. 2008 Feb 22;283(8):4501-11. [Content Brief]
- [2]. Kamani M, et al. Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism. J Biol Chem. 2011 Jun 17;286(24):21413-26. [Content Brief]
