2640117-95-7
Chemical Structure
SP16 peptide
- CAS No.: 2640117-95-7
- Formula:C102H160N24O24
- Molecular Weight:2106.51
InChIKey: DDYOOILQRNGHBZ-KSIVNIACSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CCCC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: SP16 peptide is a LRP1 signaling-activating peptide and anti-inflammatory agent that crosses the blood-brain barrier. SP16 peptide activates the Akt/ERK pro-survival signaling pathway, downregulates TLR4, and inhibits NF-κB, inflammasome formation, ROS production, pro-apoptotic signaling, caspase activity, and inflammatory cytokine release. SP16 peptide exhibits cardioprotective, neuroprotective, and analgesic effects, attenuating myocardial injury and preserving left ventricular function while alleviating allodynia and nociceptive behavior. SP16 peptide restores HIV-impaired barrier integrity and reduces HIV replication and cytokine and chemokine secretion. SP16 peptide can be used in research related to acute myocardial infarction, acute pain, inflammatory and neuropathic pain, HIV infection, and non-alcoholic fatty liver disease[1][2][3][4].
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SP16 peptide | SP16 peptide is a LRP1 signaling-activating peptide and anti-inflammatory agent that crosses the blood-brain barrier. SP16 peptide activates the Akt/ERK pro-survival signaling pathway, downregulates TLR4, and inhibits NF-κB, inflammasome formation, ROS production, pro-apoptotic signaling, caspase activity, and inflammatory cytokine release. SP16 peptide exhibits cardioprotective, neuroprotective, and analgesic effects, attenuating myocardial injury and preserving left ventricular function while alleviating allodynia and nociceptive behavior. SP16 peptide restores HIV-impaired barrier integrity and reduces HIV replication and cytokine and chemokine secretion. SP16 peptide can be used in research related to acute myocardial infarction, acute pain, inflammatory and neuropathic pain, HIV infection, and non-alcoholic fatty liver disease. | |||||||||||||||||||||
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References
- [1]. Toldo S, et al. Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction. JACC Basic Transl Sci. 2017 Oct 30;2(5):561-574. [Content Brief]
- [2]. Wang Z, et al. α1-Antitrypsin derived SP16 peptide demonstrates efficacy in rodent models of acute and neuropathic pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 Jan;36(1):e22093. [Content Brief]
- [3]. Soler Y, et al. SERPIN-Derived Small Peptide (SP16) as a Potential Therapeutic Agent against HIV-Induced Inflammatory Molecules and Viral Replication in Cells of the Central Nervous System. Cells. 2023 Feb 15;12(4):632. [Content Brief]
- [4]. Isbell M, et al. Restoration of CD4 T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC. Cancers. 2022 Nov 09;14(22):5502. [Content Brief]
