2641839-07-6
Chemical Structure
ZN-c5 hydrochloride
- CAS No.: 2641839-07-6
- Formula:C26H25ClF2N2O2
- Molecular Weight:470.94
InChIKey: QRTUELBCJFQZQU-MGARMNAFSA-N
SMILES: C[C@H]1N(C23CC(C3)C2)[C@H](C4=C(C=C(C=C4F)/C=C/C(O)=O)F)C5=C(C6=CC=CC=C6N5)C1.Cl
Biological Activity: ZN-c5 hydrochloride is a selective and orally active estrogen receptor degrader. ZN-c5 hydrochloride exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 hydrochloride inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 hydrochloride can be used for the study of breast cancer[1].
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ZN-c5 hydrochloride | ZN-c5 hydrochloride is a selective and orally active estrogen receptor degrader. ZN-c5 hydrochloride exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 hydrochloride inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 hydrochloride can be used for the study of breast cancer. | |||||||||||||||||||||
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Keywords
