2651277-02-8
Chemical Structure
Corisin
- CAS 番号: 2651277-02-8
- Formula:C84H133N25O28S
- Molecular Weight:1973.17
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](C)C(NCC(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N
Biological Activity: Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF)[1][2][3].
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Corisin | 99.45% | Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF). | ||||||||||||||||||||
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References
- [1]. Tsuruga T, et al. Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection. J Thromb Haemost. 2024;22(7):1919-1935. [Content Brief]
- [2]. Yasuma T, et al. Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging. Nat Commun. 2025;16(1):7591. Published 2025 Aug 25. [Content Brief]
- [3]. D'Alessandro-Gabazza CN, et al. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. Nat Commun. 2020;11(1):1539. Published 2020 Mar 24. [Content Brief]
