2662512-14-1
Chemical Structure
(R,R)-Birelentinib
Synonym(s): (R,R)-DZD8586
- CAS No.: 2662512-14-1
- Formula:C23H21F2N5O3
- Molecular Weight:453.45
IUPAC Name: ((2R,5R)-5-(4-amino-5-(4-(2,3-difluorophenoxy)phenyl)imidazo[5,1-f][1,2,4]triazin-7-yl)tetrahydro-2H-pyran-2-yl)methanol
InChIKey: NQJKXHPWHYRGST-GOEBONIOSA-N
SMILES: NC=1C2=C(N=C(N2N=CN1)[C@H]3CC[C@H](CO)OC3)C4=CC=C(OC5=C(F)C(F)=CC=C5)C=C4
Biological Activity: (R,R)-Birelentinib ((R,R)-DZD8586) (Compound 14) is a potent BTK inhibitor with IC50 values for BTK WT and BTK C481S of 0.7 and 0.86 nM, respectively. (R,R)-Birelentinib inhibits the self-phosphorylation of BTK and its IC50 is 24.3 nM. (R,R)-Birelentinib exhibits significant anti-proliferative activity against wild-type and C481S mutant HEK293 cells. (R,R)-Birelentinib can be used for the study of drug-resistant B-cell malignancies[1].
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(R,R)-Birelentinib | (R,R)-Birelentinib ((R,R)-DZD8586) (Compound 14) is a potent BTK inhibitor with IC50 values for BTK WT and BTK C481S of 0.7 and 0.86 nM, respectively. (R,R)-Birelentinib inhibits the self-phosphorylation of BTK and its IC50 is 24.3 nM. (R,R)-Birelentinib exhibits significant anti-proliferative activity against wild-type and C481S mutant HEK293 cells. (R,R)-Birelentinib can be used for the study of drug-resistant B-cell malignancies. | |||||||||||||||||||||
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