2675490-72-7
Chemical Structure
DIZ-3
- CAS No.: 2675490-72-7
- Formula:C46H44F2N8
- Molecular Weight:746.89
IUPAC Name: 1-(4-(5-(4-fluorophenyl)-2-(4-(4-(4-fluorophenyl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)phenyl)-1H-imidazol-4-yl)phenyl)-4-methylpiperazine
InChIKey: NHADRDLRJIYBGX-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)C3=C(NC(C4=CC=C(C=C4)C5=NC(C6=CC=C(C=C6)F)=C(N5)C7=CC=C(C=C7)N8CCN(CC8)C)=N3)C9=CC=C(C=C9)F
Biological Activity: DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1].
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DIZ-3 | DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells. | |||||||||||||||||||||
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Keywords
