2676889-05-5
Chemical Structure
Brevicidine
- CAS. Nr.: 2676889-05-5
- Formula:C74H106N18O17
- Molecular Weight:1519.74
InChIKey: UNKSYZNQRBVIFM-AGEPBGDISA-N
SMILES: O=C(N[C@@](C(NCC(N[C@H](C(O[C@@H]1C)=O)CO)=O)=O)([H])[C@@H](C)CC)[C@H]1NC([C@@H](NC([C@@H](CCCN)NC(CNC([C@H](CCCN)NC([C@@H](CCCN)NC([C@H](NC([C@H](NC([C@@H](CC(N)=O)NC(CCC(C)CC)=O)=O)CC2=CC=C(C=C2)O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O
Biological Activity: Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics[1][2].
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Brevicidine | Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics. | |||||||||||||||||||||
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References
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[1]. Zhong X, et al. Brevicidine acts as an effective sensitizer of outer membrane-impermeable conventional antibiotics for Acinetobacter baumannii treatment. Front Microbiol. 2023 Dec 15;14:1304198.
- [2]. Zhao X, et al. BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity. Front Microbiol. 2021;12:693117. Published 2021 Jun 9. [Content Brief]
