2685823-26-9
Chemical Structure
Aleniglipron
Synonym(s): GSBR-1290
- CAS No.: 2685823-26-9
- Formula:C49H55FN9O6P
- Molecular Weight:915.99
InChIKey: CPOJUYUGONJVPZ-WIXASUBBSA-N
SMILES: C[C@@H]1[C@](N2C3=CC=C(C4CCOCC4)C=C3C=C2C(N5[C@H](C6=C(N7C(N(C8=CC(NC)=C(C=C8)P(CC)(CC)=O)C=C7)=O)N(C9=CC(C)=C(C(C)=C9)F)N=C6CC5)C)=O)(C%10=NOC(N%10)=O)C1
Biological Activity: Aleniglipron (GSBR-1290) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist, with an EC50 value of less than 0.1 nM in HDB cell lines in cAMP stimulation assays. Aleniglipron selectively activates the Gαs-cAMP signaling pathway of GLP-1R without β-arrestin recruitment. Aleniglipron induces insulin release, promotes glucose clearance, reduces food intake and decreases body weight. Aleniglipron is applicable to research related to type 2 diabetes and obesity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Aleniglipron | 99.88% | Aleniglipron (GSBR-1290) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist, with an EC50 value of less than 0.1 nM in HDB cell lines in cAMP stimulation assays. Aleniglipron selectively activates the Gαs-cAMP signaling pathway of GLP-1R without β-arrestin recruitment. Aleniglipron induces insulin release, promotes glucose clearance, reduces food intake and decreases body weight. Aleniglipron is applicable to research related to type 2 diabetes and obesity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
