2700202-84-0
Chemical Structure
Shiga-Y51
- CAS No.: 2700202-84-0
- Formula:C24H20F6O6
- Molecular Weight:518.40
InChIKey: ARZKULJKLDJLJM-JMQWPVDRSA-N
SMILES: OC1=C(OC(F)(F)F)C=C(/C=C/C(C(C)(CC)C(/C=C/C2=CC=C(O)C(OC(F)(F)F)=C2)=O)=O)C=C1
Biological Activity: Shiga-Y51 is a molecular probe that can cross the blood-brain barrier and selectively bind Aβ oligomers. Shiga-Y51 can be imaged based on fluorine-19 nuclear magnetic resonance imaging (19F-MRI) technology. Shiga-Y51 exhibits extremely strong binding affinity for early to intermediate Aβ oligomers, while having almost no affinity for mature Aβ fibrils. Shiga-Y51 is a derivative of Curcumin (HY-N0005) and can inhibit the binding of Curcumin to Aβ oligomers with an IC50 of 34.61 µM. Shiga-Y51 can be used in research related to Alzheimer's disease[1][2].
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Shiga-Y51 | Shiga-Y51 is a molecular probe that can cross the blood-brain barrier and selectively bind Aβ oligomers. Shiga-Y51 can be imaged based on fluorine-19 nuclear magnetic resonance imaging (19F-MRI) technology. Shiga-Y51 exhibits extremely strong binding affinity for early to intermediate Aβ oligomers, while having almost no affinity for mature Aβ fibrils. Shiga-Y51 is a derivative of Curcumin (HY-N0005) and can inhibit the binding of Curcumin to Aβ oligomers with an IC50 of 34.61 µM. Shiga-Y51 can be used in research related to Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Yanagisawa D, et al. Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils. Biomaterials. 2021 Mar;270:120686.
- [2]. Yanagisawa D, et al. Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer's Disease. Molecules. 2021 Mar 4;26(5):1362.
