27061-78-5
Chemical Structure
Alamethicin
- CAS No.: 27061-78-5
- Formula:C92H150N22O25
- Molecular Weight:1964.34
SMILES: C(C(NC([C@@H](NC(CNC(C(NC([C@@H](NC(C(NC([C@@H](NC([C@@H](NC(C(NC([C@@H](NC(C(NC(=O)[C@H]1N(C(C(NC(C)=O)(C)C)=O)CCC1)(C)C)=O)C)=O)(C)C)=O)C)=O)CCC(N)=O)=O)(C)C)=O)[C@H](C)C)=O)(C)C)=O)=O)CC(C)C)=O)(C)C)(=O)N2[C@H](C(N[C@H](C(NC(C(NC(C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)(C)C)=O)(C)C)=O)[C@@H](C)C)=O)CCC2
Biological Activity: Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes[1][2].
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Alamethicin | 99.67% | Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes. | ||||||||||||||||||||
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- [1]. Olga S.Ostroumova, et al. Chapter Six-Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.
- [2]. Barns KJ, et al. Single-cell, time-resolved study of the effects of the antimicrobial peptide alamethicin on Bacillus subtilis. Biochim Biophys Acta. 2016 Apr;1858(4):725-32. [Content Brief]
Keywords
