2707429-60-3
2707429-60-3
Chemical Structure
Solbinsiran sodium
Synonym(s): LY3561774 sodium
- CAS No.: 2707429-60-3
- Molecular Weight:N/A
SMILES: [Solbinsiran (sodium)]
Biological Activity: Solbinsiran sodium (LY3561774 sodium) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran sodium mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran sodium lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran sodium can be used in research on mixed dyslipidemia[1][2].
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Solbinsiran sodium | Solbinsiran sodium (LY3561774 sodium) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran sodium mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran sodium lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran sodium can be used in research on mixed dyslipidemia. | |||||||||||||||||||||
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References
- [1]. Ray KK, et al. Effect of ANGPTL3 Inhibition With Solbinsiran in Preclinical and Early Human Studies. Journal of the American College of Cardiology. 2025 May 20;85(19):1803-1818. [Content Brief]
- [2]. Dudek H, et al. Abstract 12705: Identification and Characterization of Solbinsiran, a GalNAc Conjugated siRNA Targeting Angiopoietin-Like 3. Circulation. 2023;148(Suppl 1).
