2707510-30-1
Chemical Structure
GRP78-IN-3
- CAS No.: 2707510-30-1
- Formula:C17H18N4O2S
- Molecular Weight:342.42
IUPAC Name: 2-((4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-6-methoxy-2-methylquinazolin-7-yl)oxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide
InChIKey: XOWYFNSUXHAORU-AWEZNQCLSA-N
SMILES: O=C(C1=CC2=C(N1)C=CC=C2)N[C@H](C(NC3=NC=CS3)=O)C(C)C
Biological Activity: GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GRP78-IN-3 | 99.88% | GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM). | ||||||||||||||||||||
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Keywords
