2711762-70-6
Chemical Structure
RhoNox-4
- CAS No.: 2711762-70-6
- Formula:C38H44N4O8
- Molecular Weight:684.78
InChIKey: BPPNJBCDCLJSAA-UHFFFAOYSA-N
SMILES: CC(C)(OC(N1CC[N+](C2=CC3=C(C4(C5=CC=C(C=C5O3)N6CCN(C(OC(C)(C)C)=O)CC6)OC(C7=C4C=CC=C7)=O)C=C2)(CC1)[O-])=O)C
Biological Activity: RhoNox-4 is a Fe2+-selective fluorescence-activatable probe and an inhibitor of ferroptosis. RhoNox-4 shows no obvious cytotoxicity even at concentrations up to 50 μM. RhoNox-4 can selectively oxidize labile Fe2+ to Fe3+, depleting the iron pool required for lipid peroxidation and ferroptosis. RhoNox-4 inhibits ferroptosis induced by ferroptosis inducers; its activity depends on localization to the endoplasmic reticulum/Golgi apparatus, and it does not affect apoptosis or necrosis. RhoNox-4 can be used for imaging labile Fe2+ in living cells, and also enables high-throughput screening of labile iron homeostasis regulators based on 96-well plates. RhoNox-4 allows visualization of cytoplasmic Fe2+ levels in root tips of *Arabidopsis* (Ex/Em = 530-560/573-647 nm)[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RhoNox-4 | 98.65% | RhoNox-4 is a Fe2+-selective fluorescence-activatable probe and an inhibitor of ferroptosis. RhoNox-4 shows no obvious cytotoxicity even at concentrations up to 50 μM. RhoNox-4 can selectively oxidize labile Fe2+ to Fe3+, depleting the iron pool required for lipid peroxidation and ferroptosis. RhoNox-4 inhibits ferroptosis induced by ferroptosis inducers; its activity depends on localization to the endoplasmic reticulum/Golgi apparatus, and it does not affect apoptosis or necrosis. RhoNox-4 can be used for imaging labile Fe2+ in living cells, and also enables high-throughput screening of labile iron homeostasis regulators based on 96-well plates. RhoNox-4 allows visualization of cytoplasmic Fe2+ levels in root tips of *Arabidopsis* (Ex/Em = 530-560/573-647 nm). | ||||||||||||||||||||
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- [1]. Hirayama T, et al. -oxide-based and trioxolane-based fluorescent probes for monitoring labile iron and labile heme: an update. Journal of clinical biochemistry and nutrition. 2026 Jan;78(1):6-13. [Content Brief]
- [2]. Kawai K, et al. Inhibition of ferroptosis by -oxide-based fluorescent probes selective oxidation of ferrous ions. Chemical science. 2025 Jun 25;16(25):11240-11245. [Content Brief]
- [3]. Hirayama T, et al. High-Throughput Screening for the Discovery of Iron Homeostasis Modulators Using an Extremely Sensitive Fluorescent Probe. ACS sensors. 2020 Sep 25;5(9):2950-2958. [Content Brief]
- [4]. Tabata R, et al. Systemic Regulation of Iron Acquisition by Arabidopsis in Environments with Heterogeneous Iron Distributions. Plant & cell physiology. 2022 Jun 15;63(6):842-854. [Content Brief]
Keywords
