Inhibition of ferroptosis by N-oxide-based fluorescent probes via selective oxidation of ferrous ions

  • Chem Sci. 2025 May 14;16(25):11240-11245. doi: 10.1039/d4sc07972h.
Kanta Kawai  1 ,  Rie Haruki  2 ,  Shunsuke Nozawa  2 ,  Hideko Nagasawa  1 ,  Tasuku Hirayama  1  3
Affiliations
  • 1. Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University 1-25-4, Daigaku-nishi Gifu 501-1196 Japan.
  • 2. Institute of Materials Structure Science, High Energy Accelerator Research Organization 1-1 Oho Tsukuba Ibaraki 305-0801 Japan.
  • 3. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan [email protected].
PMID: 40401188 DOI: 10.1039/d4sc07972h
Abstract

Ferroptosis, a form of iron-dependent programmed cell death, is linked to various diseases and physiological processes. Despite the availability of various types of Ferroptosis inducers, its inhibitors are limited to iron chelators or radical scavengers. This study demonstrates that Fe(ii)-selective fluorescent probes developed in our lab could serve as Ferroptosis inhibitors via selective oxidation of Fe(ii), which is required for lipid peroxidation. This finding opens the door to a new class of Ferroptosis inhibitors with potential therapeutic applications.

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