2715104-46-2
Chemical Structure
PROTAC HMGCR Degrader-2
- CAS No.: 2715104-46-2
- Formula:C53H79N5O10S
- Molecular Weight:978.29
InChIKey: YASBQIQZXTUKLR-XQKMAAOKSA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCCNC(O[C@@H]4[C@@]5([H])C(C=C[C@@H]([C@@H]5CC[C@@H](O)C[C@@H](O)CC(O)=O)C)=C[C@@H](C4)C)=O)=O
Biological Activity: PROTAC HMGCR Degrader-2 is a HMGCR PROTAC degrader with an IC50 value of 0.25 μM. PROTAC degrades HMGCR-2 in Insig-silenced HepG2 cells with a DC50 of 0.12 μM. PROTAC HMGCR Degrader-2 takes PROTAC HMGCR Degrader-1 (HY-171823) as the oral prodrug. PROTAC HMGCR Degrader-2 degrades HMGCR by the VHL-dependent ubiquitin-proteasome system and reduces cellular cholesterol in HepG2 cells. PROTAC CDK2/4/6 Degrader-2 can be used for hyperlipidemia research[1].
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PROTAC HMGCR Degrader-2 | PROTAC HMGCR Degrader-2 is a HMGCR PROTAC degrader with an IC50 value of 0.25 μM. PROTAC degrades HMGCR-2 in Insig-silenced HepG2 cells with a DC50 of 0.12 μM. PROTAC HMGCR Degrader-2 takes PROTAC HMGCR Degrader-1 (HY-171823) as the oral prodrug. PROTAC HMGCR Degrader-2 degrades HMGCR by the VHL-dependent ubiquitin-proteasome system and reduces cellular cholesterol in HepG2 cells. PROTAC CDK2/4/6 Degrader-2 can be used for hyperlipidemia research. | |||||||||||||||||||||
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Keywords
