2726463-68-7
Chemical Structure
EGFR-IN-30
- CAS No.: 2726463-68-7
- Formula:C28H33BrN7O2P
- Molecular Weight:610.49
IUPAC Name: (2-((5-bromo-2-((6-isopropyl-8-methoxy-3-methyl-3,4,5,6-tetrahydrobenzo[b]pyrazolo[4,3-d]azepin-9-yl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
InChIKey: GPRZWEDMKSTCPZ-UHFFFAOYSA-N
SMILES: O=P(C)(C)C1=C(NC2=NC(NC3=C(OC)C=C4N(C(C)C)CCC5=C(C=NN5C)C4=C3)=NC=C2Br)C=CC=C1
Biological Activity: EGFR-IN-30 is a potent EGFR inhibitor with IC50s of 1-10 nM, <1 nM for EGFR (WT), EGFR (L858R/T790M/C797S), respectively. EGFR-IN-30 has potential for cell proliferative diseases, such as cancer research[1].
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EGFR-IN-30 | EGFR-IN-30 is a potent EGFR inhibitor with IC50s of 1-10 nM, <1 nM for EGFR (WT), EGFR (L858R/T790M/C797S), respectively. EGFR-IN-30 has potential for cell proliferative diseases, such as cancer research. | |||||||||||||||||||||
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Keywords
