2731-16-0
Chemical Structure
N-Deacetylthiocolchicine
- CAS No.: 2731-16-0
- Formula:C20H23NO4S
- Molecular Weight:373.47
IUPAC Name: (S)-7-amino-1,2,3-trimethoxy-10-(methylthio)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
InChIKey: NUNCOHUMTCDISK-AWEZNQCLSA-N
SMILES: COC1=C(C(C([C@@H](N)CC2)=C3)=CC=C(SC)C3=O)C2=CC(OC)=C1OC
Biological Activity: N-Deacetylthiocolchicine is a tubulin inhibitor with an IC50 value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer[1][2].
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N-Deacetylthiocolchicine | N-Deacetylthiocolchicine is a tubulin inhibitor with an IC50 value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer. | |||||||||||||||||||||
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- [1]. Gelmi ML, et al. N-deacetyl-N-aminoacylthiocolchicine derivatives: synthesis and biological evaluation on MDR-positive and MDR-negative human cancer cell lines. J Med Chem. 1999 Dec 16;42(25):5272-6. [Content Brief]
- [2]. Barešić M, et al. Different Therapeutic Paths (Colchicine vs. Anakinra) in Two Patients With Schnitzler's Syndrome. Arch Rheumatol. 2016 Jul 11;31(4):377-380. [Content Brief]
Keywords
