2734918-37-5
Chemical Structure
JAK1/TYK2-IN-3
- No. CAS: 2734918-37-5
- Formula:C17H21F2N7O
- Molecular Weight:377.39
IUPAC Name: 8-(2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
InChIKey: ROOUYRXCMOACDH-UHFFFAOYSA-N
SMILES: O=C1NCCC12CCN(C3=NC(NC4=CN(C(F)F)N=C4)=NC=C3C)CC2
Biological Activity: JAK1/TYK2-IN-3 is a potent, selective and orally active dual TYK2/JAK1 inhibitor with IC50 values of 6 and 37 nM, respectively. JAK1/TYK2-IN-3 also shows selectively relative to JAK2 (IC50=140 nM) and JAK3 (IC50=362 nM). JAK1/TYK2-IN-3 shows anti-inflammatory effect by regulating the expression of related TYK2/JAK1-regulated genes, as well as the formation of Th1, Th2, and Th17 cells[1].
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JAK1/TYK2-IN-3 | JAK1/TYK2-IN-3 is a potent, selective and orally active dual TYK2/JAK1 inhibitor with IC50 values of 6 and 37 nM, respectively. JAK1/TYK2-IN-3 also shows selectively relative to JAK2 (IC50=140 nM) and JAK3 (IC50=362 nM). JAK1/TYK2-IN-3 shows anti-inflammatory effect by regulating the expression of related TYK2/JAK1-regulated genes, as well as the formation of Th1, Th2, and Th17 cells. | |||||||||||||||||||||
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