2741300-61-6
Chemical Structure
K-Ras ligand-Linker Conjugate 2
- CAS No.: 2741300-61-6
- Formula:C45H58N8O7
- Molecular Weight:822.99
IUPAC Name: benzyl (S)-4-(2-(((2S,4R)-4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-2-(cyanomethyl)piperazine-1-carboxylate
InChIKey: IWTUIAHWVUGDQV-XEZIGOATSA-N
SMILES: NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1
Biological Activity: K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
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K-Ras ligand-Linker Conjugate 2 | K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells. | |||||||||||||||||||||
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Keywords
