2745108-35-2
2745108-35-2
Chemical Structure
TOPK-p38/JNK-IN-1
- CAS No.: 2745108-35-2
- Formula:C17H15F3N2O4
- Molecular Weight:368.31
IUPAC Name: 1-(5-acetyl-4-hydroxy-2-methoxyphenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChIKey: GHJDMUOTXYVBEB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC(C(C)=O)=C(O)C=C2OC
Biological Activity: TOPK-p38/JNK-IN-1 (Compound B12) is an orally active TOPK-p38/JNK signaling pathway inhibitor with the IC50 value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK[1].
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TOPK-p38/JNK-IN-1 | TOPK-p38/JNK-IN-1 (Compound B12) is an orally active TOPK-p38/JNK signaling pathway inhibitor with the IC50 value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK. | |||||||||||||||||||||
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References
Keywords
